Pelargonium – the most tested plant with most clinical evidence in the treatment of viral respiratory infections

Pelargonium sidoides (South African nutmeg, Umckaloabo) is a flowering plant that originates from Africa, and it is decorated with a beautiful flower of unusual purple-red color.

Pelargonium – the most tested plant with most clinical evidence in the treatment of viral respiratory infections

Thanks to the evidence provided by numerous studies, today, Pelargonium is registered in Western European countries as a medicine for the treatment of respiratory infections.

Cochrane, as the most relevant in the evaluation of summarized results of clinical studies, gives a positive conclusion based on 10 studies: Pelargonium is effective in treating and reducing the symptoms of acute rhinosinusitis, cold, acute bronchitis and sinusitis.

Based on numerous clinical studies related to the effectiveness and efficacy of Pelargonium, a confirmation of effectiveness was given by leading European institutions:

The European Respiratory Society lists Pelargonium extract as a natural component in the treatment of symptoms of acute bronchitis.

– NICE, the UK National Guide since 2019, recommends Pelargonium as the first line of cough treatment.

Traditional medicine

Although it was being used in Africa for centuries, the healing properties of Pelargonium were first introduced in Great Britain in 1897. The medicinal properties of the plant were introduced to Europe by Charles Henry Stevens. He actually discovered its effect on tuberculosis, so this plant is considered to be the first medicine for tuberculosis, at that time known in Great Britain as the “Stevens’ medicine”.

It has been traditionally used since the 19th century for the treatment of cough, cold, irritations of the upper respiratory system, tuberculosis, gastrointestinal system.

A standardized Pelargonium root extract is used as an ingredient in Viranta Forte syrup.

Viranto Forte with Pelargonium in its composition is intended for children older than 3 years for the treatment of cold and flu, or for the treatment of viral infections of the upper respiratory tract:

– Tonsillitis (tonsil inflammation)

– Pharyngitis and laryngitis (throat inflammation)

– Acute sinusitis (acute inflammation of the sinuses)

– Acute bronchitis

Studies and sources:

Haidvogl M, Heger M. (2007) Treatment effect and safety of EPs® 7630-solution in acute bronchitis in childhood: report of a multicentre observational study. Phytomedicine.;14 Suppl 6:60–64.

H. Matthys, W. Kamin, P. Funk, M. Heger. (2007) Pelargonium sidoides preparation (EPs® 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine.14 Suppl 6:69–73.

Timmer, J. Günther, G. Rücker, E. Motschall, G. Antes, W.V. Kern. (2008) Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst Rev. (3):CD006323.

T.B. Agbabiaka, R. Guo, E. Ernst (2008) Pelargonium sidoides for acute bronchitis: A systematic review and meta-analysis. Phytomedicine (15); 378–385.

H. Kolodziej. (2011) Antimicrobial, Antiviral and Immunomodulatory Activity Studies of Pelargonium sidoides in the Context of Health Promotion Pharmaceuticals. 4, 1295-1314.

T. Patiroglu, A. Tunc, H.E. Gungor, E. Unal (2012) The Efficacy of Pelargonium sidoides in the Treatment of Upper Respiratory Tract Infections in Children With Transient Hypogammaglobulinemia of Infancy. Phytomedicine, 19 (11), 958-61.

V.G. Lizogub, D.S. Riley, M. Heger. (2007) Efficacy of a Pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore (NY). 3(6):573-584.

H. Matthys, W. Lehmacher, A. Zimmermann, J. Brandes, W. Kamin. (2016) EPs 7630 in acute respiratory tract infections – a systematic review and meta-analysis of randomized clinical trials. J Lung PulmRespir Res.3(1):00068.

K. Mejkal, V. Rjakšova. (2016) Use of plant extracts as an efficient alternative therapy of respiratory tract infections. Čes. slov. Farm. 65, 139–160.

D. Careddu, A. Pettenazzo (2018) Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children. International Journal of General Medicine. (11); 91–98

EMA/HMPC/444251/2015  05 June 2018 Committee on Herbal Medicinal Products (HMPC) Assessment report on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. Based on Article 16d (1), Article 16f and Article 16h of Directive 2001/83/EC (traditional use).

https://pubmed.ncbi.nlm.nih.gov/24146345/

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