Ferroly

Ferroly for you! is intended for iron supplementation in cases of iron deficiency and iron deficiency anemia.

It contains a modern form of iron — ferrous bisglycinate chelate — characterized by high bioavailability (absorption) and excellent tolerability.

Iron is an essential mineral involved in hemoglobin synthesis and oxygen transport throughout the body. Its deficiency leads to reduced production of red blood cells (erythrocytes) and the development of iron deficiency anemia, which manifests through symptoms such as fatigue, weakness, paleness, and reduced concentration. It is important to emphasize that, unlike in adults, iron deficiency in infants and young children represents a neurodevelopmental risk factor. During critical periods of brain development, iron deficiency may lead to consequences affecting a child’s cognitive and motor functions.

Clinical data show that ferrous bisglycinate has significantly higher bioavailability compared to ferrous sulfate, along with better tolerability, which is particularly important in children and individuals sensitive to gastrointestinal adverse effects (Pineda and Ashmead, Nutrition, 2001).

Randomized studies confirm that the use of iron bisglycinate chelate leads to a more effective increase in ferritin levels (iron stores) compared to iron polymaltose complex, with a favorable safety profile (Name et al., Current Pediatric Reviews, 2018).

Sources

Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001;17(5):381–384. Clinical study confirming that ferrous bisglycinate chelate has a bioavailability of 90.9% compared to 26.7% for ferrous sulfate, making it a form of iron with excellent absorption and tolerability in infants and young children with iron deficiency anemia.
https://pubmed.ncbi.nlm.nih.gov/11377130/

Name JJ, Vasconcelos AR, Valzachi Rocha Maluf MC. Iron bisglycinate chelate and polymaltose iron for the treatment of iron deficiency anemia: A pilot randomized trial. Current Pediatric Reviews. 2018;14(4):261–268. Randomized double-blind study confirming the greater effectiveness of iron bisglycinate chelate in increasing ferritin levels (iron stores) compared to iron polymaltose complex in children with iron deficiency anemia, with excellent tolerability.
https://pubmed.ncbi.nlm.nih.gov/30280670/

Ferroly can be used from the first day of life. It is formulated to meet the needs of the most sensitive groups — preterm infants, newborns, children, pregnant women, and breastfeeding mothers.

Clinical studies confirm that iron bisglycinate chelate can be safely used in infants and young children, with good tolerability. In a study conducted in infants and young children with iron deficiency anemia, this form of iron demonstrated high bioavailability: 90.9% compared to 26.7% for ferrous sulfate (Pineda and Ashmead, Nutrition, 2001).

A study conducted in preterm infants, a highly sensitive population, showed that ferrous bisglycinate administered at a four-times lower dose achieved the same clinical effect as the standard dose of ferrous sulfate (Bagna and Spada, Curr Pediatr Rev. 2018).

A study in pregnant women demonstrated that a two-times lower dose of iron in the form of bisglycinate (25 mg) was equally effective as the standard sulfate dose (50 mg) (Milman and Jønsson, J Perinat Med. 2014).

Sources

Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001;17(5):381–384. Clinical study confirming the safety and efficacy of ferrous bisglycinate chelate in infants from 6 months of age, with excellent tolerability and absorption regulated according to the body’s needs.
https://pubmed.ncbi.nlm.nih.gov/11377130/

Bagna R, Spada E, Mazzone R, Saracco P, Boetti T, Cester EA, Bertino E, Coscia A. Efficacy of Supplementation with Iron Sulfate Compared to Iron Bisglycinate Chelate in Preterm Infants. Curr Pediatr Rev. 2018;14(2):123-129. Retrospective study involving 300 preterm infants (≤32 weeks) demonstrating that iron bisglycinate chelate at a dose of 0.75 mg/kg/day achieves the same efficacy as iron sulfate at a dose of 3 mg/kg/day.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6416193/

Milman N, Jønsson L, Dyre P, Pedersen PL, Larsen LG. Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med. 2014;42(2):197-206. Randomized double-blind study involving 80 pregnant women showing that ferrous bisglycinate at 25 mg/day prevents anemia as effectively as ferrous sulfate at 50 mg/day, with better tolerability.
https://pubmed.ncbi.nlm.nih.gov/24152889/

The chelated stable structure ensures stability in the digestive tract and in the acidic environment of the stomach. The molecule is not released in the stomach, thereby reducing the risk of stomach irritation and adverse effects such as nausea and abdominal pain.

The neutral stable structure enables a dual absorption pathway in the small intestine and protection against interactions with food, contributing to high bioavailability.

Clinical data show that ferrous bisglycinate chelate has significantly higher absorption compared to standard inorganic iron salts, with values reaching approximately 90%, compared to substantially lower values observed with ferrous sulfate (Pineda and Ashmead, Nutrition, 2001).

Source

Pineda O, Ashmead HD. Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001;17(5):381–384. Clinical study confirming the stability and high bioavailability (90.9%).
https://pubmed.ncbi.nlm.nih.gov/11377130/ 

Ferroly provides stable and predictable iron intake with reduced influence from dietary factors. Thanks to its high stability in the digestive tract, absorption is less affected by food inhibitors such as phytates, polyphenols, and calcium, contributing to a more consistent effect and better iron utilization in the body.

Studies in which iron preparations were administered together with milk demonstrated that bisglycinate maintained up to 2.5 times higher absorption compared to iron sulfate under the same conditions.

Ferroly can also be taken with meals, making administration easier and supporting regular use.

Source

Bovell-Benjamin AC, Viteri FE, Allen LH. Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000;71(6):1563-1569. Study demonstrating that iron absorption from bisglycinate chelate in whole maize is regulated according to the body’s iron status and does not enter the common intestinal pool with iron from ferrous sulfate, indicating a distinct absorption mechanism.
https://pubmed.ncbi.nlm.nih.gov/10837299/ 

Thanks to its stable chelated complex and reduced amount of free iron in the digestive tract, Ferroly contributes to good gastrointestinal tolerability. Lower levels of free iron in the intestinal lumen are associated with a reduced risk of mucosal irritation and adverse effects compared to conventional forms of iron (such as nausea, abdominal pain, and constipation).

In a randomized double-blind study, iron bisglycinate chelate demonstrated significantly better tolerability compared to ferrous sulfate, with a lower incidence of moderate to severe gastrointestinal adverse effects (Coplin et al., Clinical Therapeutics, 1991).

Source

Coplin M, Schuette S, Leichtmann G, Lashner B. Tolerability of iron: a comparison of bis-glycino iron II and ferrous sulphate. Clinical Therapeutics. 1991;13(5):606–612. Randomized double-blind crossover study confirming that iron bisglycinate chelate, due to the reduced amount of free iron in the intestinal lumen, demonstrates better gastrointestinal tolerability compared to ferrous sulfate.
https://pubmed.ncbi.nlm.nih.gov/1799918/

Ferroly enables precise dosing according to age — in drops or milliliters.

Thanks to the graduated dropper, administration is simple and accurate. The dose can be measured precisely, which is especially important in children.

The elemental iron content in the product is clearly defined:

1 milliliter contains 10 milligrams of elemental iron.

1 drop contains 1 milligram of elemental iron.

In iron deficiency anemia, it is extremely important not only to normalize hemoglobin levels, but also to replenish iron stores. For this reason, supplementation for three months is necessary. If supplementation is discontinued earlier, there is a risk that iron stores remain depleted and anemia may recur. Ferritin is the parameter that indicates the status of iron stores.

Ferrous bisglycinate chelate enables efficient absorption and better utilization of iron for restoring iron stores. Clinical data show that this form of iron leads to a significant increase in ferritin levels, indicating the replenishment of iron stores and stabilization of iron status in the body (Name et al., Current Pediatric Reviews, 2018).

Source

Name JJ, Vasconcelos AR, Valzachi Rocha Maluf MC. Iron bisglycinate chelate and polymaltose iron for the treatment of iron deficiency anemia: A pilot randomized trial. Current Pediatric Reviews. 2018;14(4):261–268. Randomized study confirming that iron bisglycinate chelate significantly increases ferritin levels and restores iron stores in the body compared to iron polymaltose complex, representing a key marker of adequate and long-term correction of iron deficiency anemia.
https://pubmed.ncbi.nlm.nih.gov/30280670/

Ferroly has a mild and pleasant taste, without the pronounced metallic aftertaste commonly associated with conventional iron supplements.

Its stable chelated structure enables minimal contact of free iron with taste receptors, contributing to the reduction of metallic taste.

The pleasant taste contributes to better acceptance, especially in children, and facilitates regular use.

Ferroly can be taken regardless of meals, including together with food. Thanks to the stability of its formulation, Ferroly is less affected by dietary components, allowing greater flexibility and easier everyday use.